Scientific Summaries
At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.
Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.
Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.
Vagus nerve stimulation has a positive effect on mood in patients with refractory epilepsy
Klinkenberg S, Majoie HJ, van der Heijden MM, Rijkers K, Leenen L, Aldenkamp AP.
Clinical Neurology and Neurosurgery 114 (2012) 336–340
Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design
Have a look at the study design of the upcoming PRediction of vagal nerve stimulation EfficaCy In drug-reSistant Epilepsy (PRECISE) study, by Dolezalova et al. 2022, that was recently published in frontiers in Neurology.
Connectomic profiling and Vagus nerve stimulation Outcomes Study (CONNECTiVOS): a prospective observational protocol to identify biomarkers of seizure response in children and youth
Siegel L, Yan H, Warsi N, Wong S, Suresh H, Weil AG, Ragheb J, Wang S, Rozzelle C, Albert GW, Raskin J, Abel T, Hauptman J, Schrader DV, Bollo R, Smyth MD, Lew SM, Lopresti M, Kizek DJ, Weiner HL, Fallah A, Widjaja E, Ibrahim GM.
BMJ Open 2022;12:e055886.
The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: The PuLsE (Open Prospective Randomized Long-term Effectiveness) trial
Ryvlin P, Gilliam FG, Nguyen DK, Colicchio G, Iudice A, Tinuper P, Zamponi N, Aguglia U, Wagner L, Minotti L, Stefan H, Boon P, Sadler M, Benna P, Raman P, Perucca E.
Epilepsia, 55(6):893–900, 2014
Vagus nerve stimulation therapy in people with drug-resistant epilepsy (CORE-VNS): rationale and design of a real-world post-market comprehensive outcomes registry.
Sen A, Verner R, Valeriano JP, Lee R, Zafar M, Thomas R, Kotulska K, Jespers E, Dibué M, Kwan P
BMJ Neurol Open 2021;3:e000218
Effect of Long-Term Treatment with Vagus Nerve Stimulation on Mood and Quality of Life in Korean Patients with Drug-Resistant Epilepsy.
Kim JS, Kim DY, Jo HJ, Hwang YH, Song JY, Yang KI, Hong SB.
J Clin Neurol 2021;17(3):385-392