Scientific Summaries
At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.
Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.
Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.
Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy
Schomer AC, Nearing BD, Schachter SC, Verrier RL.
Epilepsia. 2014 Dec;55(12):1996-2002.
Long-term follow-up of vagus nerve stimulation in drug-resistant KCNT1-related epilepsy: a case presentation
Wang, M., Geng, G., Meng, Y. et al.
Acta Epileptologica 4, 34 (2022).
Scheduled Programming of VNS Therapy Reduces Time-To-Dose and Office Visits in the COVID-19 Pandemic (P5-1.006)
Maxine Dibue, Roshani Patel, Michal Tzadok, Firas Fahoum, Charles Gordon, Riem El Tahry
Neurology Apr 2023, 100 (17 Supplement 2) 3974;
The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy: a meta-analysis
Hajtovic S, LoPresti MA, Zhang L, Katlowitz KA, Kizek DJ, Lam S.
J Neurosurg Pediatr. 2022 Mar 18:1-14.
Vagus nerve stimulation for treatment of epilepsy in Rett syndrome
Dev Med Child Neurol. 2006 Aug;48(8):683-6.
doi: 10.1017/S0012162206001435. PMID: 16836782.
Vagus nerve stimulation for drug-resistant epilepsy induced by tuberous sclerosis complex
Tong X, Wang X, Qin L, Zhou J, Guan Y, Teng P, Wang J, Yang Y, Li T, Luan G.
Epilepsy Behav. 2022 Jan;126:108431.
Vagus Nerve Stimulation for Refractory Epilepsy in Tuberous Sclerosis
Zamponi N, Petrelli C, Passamonti C, Moavero R, Curatolo P.
Pediatr Neurol. 2010 Jul;43(1):29-34.
Impact of Vagus Nerve Stimulation for the Treatment of Drug-Resistant Epilepsy on Patterns of Use and Cost of Health Care Services and Pharmacotherapy [...]
Evans K, Stamas N, Li Q, Vincent T, Halchenko Y, Zhang L, Danielson V, Murphy J, Barion F, Lam S, Lassagne R, Berger A.
Clin Ther. 2023 Feb 4:S0149-2918(23)00027-9.
Refractory epilepsy in tuberous sclerosis: Vagus nerve stimulation with or without subsequent resective surgery
Wang, M., Geng, G., Meng, Y. et al.
Acta Epileptologica 4, 34 (2022).
Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex
Major P, Thiele EA.
Epilepsy Behav. 2008 Aug;13(2):357-60.
Alteration in brain connectivity in patients with Dravet syndrome after vagus nerve stimulation (VNS): exploration of its effectiveness using graph theory analysis with electroencephalography
Wang ZJ, Kim ES, Noh BH, Liang JG, Lee D, Hur YJ, Kim NY, Kim HD.
J Neural Eng. 2020 Jun 22;17(3):036014.
Efficacy of adjunctive vagus nerve stimulation in patients with Dravet syndrome: A meta-analysis of 68 patients
Dibué-Adjei M, Fischer I, Steiger HJ, Kamp MA.
Seizure. 2017 Aug;50:147-152.
Long-term results of vagus nerve stimulation in children with Dravet syndrome: Time-dependent, delayed antiepileptic effect
Youn SE, Jung DE, Kang HC, Kim HD.
Epilepsy Res. 2021 Aug;174:106665.
Nonpharmacologic care for patients with Lennox-Gastautsyndrome: Ketogenic diets and vagus nerve stimulation
Kossoff EH, Shields WD.
Epilepsia. 2014 Sep;55 Suppl 4:29-33.
The efficacy and tolerability of auto-stimulation-VNS in children with Lennox-Gastaut syndrome
Kossoff EH, Shields WD.
Epilepsia. 2014 Sep;55 Suppl 4:29-33.
Rapid titration of VNS therapy reduces time-to-response in epilepsy
Tzadok M, Verner R, Kann L, Tungala D, Gordon C, El Tahry R, Fahoum F.
Epilepsy Behav. 2022 Sep;134:108861.
Vagus nerve stimulation outcome prediction: from simple parameters to advanced models
Chrastina J, Novak Z, Zeman T, Dolezalova I, Zatloukalova E, Brazdil M.
Bratisl Lek Listy. 2022;123(9):641-647.
Vagus nerve stimulation in patients with Lennox-Gastaut syndrome: A meta-analysis
Dibué M, Greco T, Spoor JKH, Tahir Z, Specchio N, Hänggi D, Steiger HJ, Kamp MA.
Acta Neurol Scand. 2021 May;143(5):497-508.
Vagus nerve stimulation and Lennox-Gastaut syndrome: a review of the literature and data from the VNS patient registry
Karceski S.
CNS Spectr. 2001 Sep;6(9):766-70.
Vagus nerve stimulation for refractory posttraumatic epilepsy: Efficacy and predictors of seizure outcome
Guo M, Wang J, Tang C, Deng J, Zhang J, Xiong Z, Liu S, Guan Y, Zhou J, Zhai F, Luan G, Li T
Front Neurol. 2022 Jul 28;13:954509