The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy: a meta-analysis
Hajtovic S, LoPresti MA, Zhang L, Katlowitz KA, Kizek DJ, Lam S.
J Neurosurg Pediatr. 2022 Mar 18:1-14.
https://doi.org/10.3171/2022.1.PEDS222.
For the current theme - vagus nerve stimulation (#VNS) in Rett syndrome, this #meta-analysis by Hajtovic et al. (2022) examined the effect of VNS on #seizure control in #pediatric patients with genetic etiologies of epilepsy. The study included 47 publications with 216 pediatric patients in total. Noteworthy, due to the rare cases of Rett syndrome, there is limited clinical evidence for the effectiveness of VNS on this specific syndrome, only 11 patients (5 publications) with Rett syndrome could be identified. Overall, 9 out of 11 patients (81.8%) obtained > 50% seizure reduction. Improved alertness was reported in one study.
Due to the limited sample size, different clinical features, and various endpoints among the five publications, it is challenging to compare and combine this data. Thus, further studies with larger sample sizes and consistent clinical features and treatment outcomes are required to confirm the observed results.
To know more about Rett syndrome, VNS Therapy, or our company, check out these websites:
International Rett Syndrome Foundation: https://lnkd.in/djT5kam
Rett Syndrome Europe: https://lnkd.in/eSvGCp83
Nationellt Center för Rett Syndrom & Närliggande Diagnoser: https://lnkd.in/ervKfD-i
VNS Therapy: https://lnkd.in/ejjZ3RD4
Go North Medical: https://lnkd.in/eUKuEfbM
Link to the article:
