Scientific Summaries
At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.
Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.
Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.
Vagus nerve stimulation for drug-resistant epilepsy induced by tuberous sclerosis complex
Tong X, Wang X, Qin L, Zhou J, Guan Y, Teng P, Wang J, Yang Y, Li T, Luan G.
Epilepsy Behav. 2022 Jan;126:108431.
Vagus Nerve Stimulation for Refractory Epilepsy in Tuberous Sclerosis
Zamponi N, Petrelli C, Passamonti C, Moavero R, Curatolo P.
Pediatr Neurol. 2010 Jul;43(1):29-34.
Refractory epilepsy in tuberous sclerosis: Vagus nerve stimulation with or without subsequent resective surgery
Wang, M., Geng, G., Meng, Y. et al.
Acta Epileptologica 4, 34 (2022).
Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex
Major P, Thiele EA.
Epilepsy Behav. 2008 Aug;13(2):357-60.
The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy: a meta-analysis.
Many caregivers are concerned about the potential long-term effects of using antiseizure medications (#ASMs) and how it may affect their children’s intelligence.
Vagus nerve stimulation in children with drug-resistant epilepsy of monogenic etiology
Xie H, Ma J, Ji T, Liu Q, Cai L, Wu Y.
Front Neurol. 2022 Sep 1;13:951850.
Difficult-to-Treat Depression and the Role of Vagus Nerve Stimulation
R. Hamish McAllister-Williams, PhD, MD, FRCPsych and Tiago Costa, MBBS, MRCPsych
Psychiatr Ann. 2022;52(7):266–271 English.
Vagus nerve stimulation has a positive effect on mood in patients with refractory epilepsy
Klinkenberg S, Majoie HJ, van der Heijden MM, Rijkers K, Leenen L, Aldenkamp AP.
Clinical Neurology and Neurosurgery 114 (2012) 336–340
Subgroup analysis of seizure and cognitive outcome after vagal nerve stimulator implantation in children
Knorr C, Greuter L, Constantini S, Fried I, Kremer U, Datta AN, Guzman R, Soleman J.
Child's Nervous System volume 37, pages243–252 (2021)
Improved quality of life and cognition after early vagal nerve stimulator implantation in children
Soleman J, Stein M, Knorr C, Datta AN, Constantini S, Fried I, Guzman R, Kramer U.
Epilepsy & Behavior 88 (2018) 139–145
A 6-Year Follow-up Study of Vagus Nerve Stimulation Effect on Quality of Life in Treatment-Resistant Depression A Pilot Study
Trottier-Duclos F, Desbeaumes Jodoin V, Fournier-Gosselin MP, Richer F, Desjardins N, Tieu S, Lespérance P.
Journal of ECT • Volume 00, Number 00, Month 2018
Quality-of-life metrics with vagus nerve stimulation for epilepsy from provider survey data
Englot DJ, Hassnain KH, Rolston JD, Harward SC, Sinha SR, Haglund MM.
Epilepsy & Behavior 66 (2017) 4–9
Management and outcome of vagus nerve stimulator implantation: experience of an otolaryngeal/neuropediatric cooperation
Grasl S, Janik S, Dressler A, Diehm R, Gröppel G, Eichinger K, Grasl MC, Gstoettner W, Feucht M, Vyskocil E, Baumgartner WD.
European Archives of Oto-Rhino-Laryngology (2021) 278:3891–3899
The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: The PuLsE (Open Prospective Randomized Long-term Effectiveness) trial
Ryvlin P, Gilliam FG, Nguyen DK, Colicchio G, Iudice A, Tinuper P, Zamponi N, Aguglia U, Wagner L, Minotti L, Stefan H, Boon P, Sadler M, Benna P, Raman P, Perucca E.
Epilepsia, 55(6):893–900, 2014
Efficacy and tolerability of vagus nerve stimulation therapy (VNS) in Slovenian epilepsy patients: younger age and shorter duration of epilepsy might result in better outcome
Kavčič A, Kajdič N, Rener-Primec Z, Krajnc N, Žgur T.
Acta Clin Croat. 2019 Jun; 58(2): 255–264.
Vagus nerve stimulation: An update on a novel treatment for treatment-resistant depression
Kamel LY, Xiong W, Gott BM, Kumar A, Conway CR.
J Neurol Sci. 2022 Mar 15;434:120171.
The role of vagus nerve stimulation in the treatment of refractory epilepsy: clinical outcomes and impact onquality of life.
Martorell-Llobregat C, González-López P, Luna E, Asensio-Asensio M, Jadraque-Rodríguez R, García-March G, Moreno-López P.
Neurologia (Engl Ed). 2021 Jun1;S2173-5808(21)00073-0
Effect of Long-Term Treatment with Vagus Nerve Stimulation on Mood and Quality of Life in Korean Patients with Drug-Resistant Epilepsy.
Kim JS, Kim DY, Jo HJ, Hwang YH, Song JY, Yang KI, Hong SB.
J Clin Neurol 2021;17(3):385-392