Scientific Summaries

At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.

Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.

Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.

Rodrigo Silva 6/8/22 Rodrigo Silva 6/8/22

Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy

Pitkänen A, Sutula TP.

Lancet Neurol. 2002 Jul;1(3):173-81.

Rodrigo Silva 6/7/22 Rodrigo Silva 6/7/22

Up to What Extent Does Dravet Syndrome Benefit From Neurostimulation Techniques?

Jiangwei Ding, Lei Wang, Wenchao Li, Yangyang Wang, Shucai Jiang, Lifei Xiao, Changliang Zhu, Xiaoyan Hao, Jiali Zhao, Xuerui Kong, Ziqin Wang, Guangyuan Lu, Feng Wang and Tao Sun

Front Neurol. 2022 Apr 13;13:843975

Rodrigo Silva 6/1/22 Rodrigo Silva 6/1/22

Clinical perspectives on vagus nerve stimulation: present and future

This work by Goggins et al. (May 2022) reviewed the #preclinical and #clinical evidence for evaluating the treatment effect of vagus nerve stimulation (#VNS) in drug resistant epilepsy (#DRE).

$Vagus nerve stimulation has a positive effect on mood in patients with refractory epilepsy$

Rodrigo Silva 5/30/22 Rodrigo Silva 5/30/22

Vagus nerve stimulation has a positive effect on mood in patients with refractory epilepsy

Klinkenberg S, Majoie HJ, van der Heijden MM, Rijkers K, Leenen L, Aldenkamp AP.

Clinical Neurology and Neurosurgery 114 (2012) 336–340

Rodrigo Silva 5/25/22 Rodrigo Silva 5/25/22

Accurate identification of EEG recordings with interictal epileptiform discharges using a hybrid approach: Artificial intelligence supervised by human experts

Kural MA, Jing J, Fürbass F, Perko H, Qerama E, Johnsen B, Fuchs S, Westover MB, Beniczky S.

Epilepsia. 2022;00:1–10.

Rodrigo Silva 5/23/22 Rodrigo Silva 5/23/22

Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design

Have a look at the study design of the upcoming PRediction of vagal nerve stimulation EfficaCy In drug-reSistant Epilepsy (PRECISE) study, by Dolezalova et al. 2022, that was recently published in frontiers in Neurology.

Rodrigo Silva 5/12/22 Rodrigo Silva 5/12/22

Observations on the Use of Vagus Nerve Stimulation Earlier in the Course of Pharmacoresistant Epilepsy: Patients With Seizures for Six Years or Less

Helmers SL, Griesemer DA, Dean JC, Sanchez JD, Labar D, Murphy JV, Bettis D, Park YD, Shuman RM, Morris GL 3rd.

The Neurologist: May 2003 - Volume 9 - Issue 3 - p 160-164

Rodrigo Silva 5/11/22 Rodrigo Silva 5/11/22

Vagus Nerve Stimulation in Intractable Epilepsy

This study by Boluk et al. 2022 evaluated the efficiency and safety of vagus nerve stimulation (#VNS) in different types of #refractory epilepsy based on a single center experience at Istanbul University-Cerrahpasa, Turkey.

Rodrigo Silva 4/13/22 Rodrigo Silva 4/13/22

A 6-Year Follow-up Study of Vagus Nerve Stimulation Effect on Quality of Life in Treatment-Resistant Depression A Pilot Study

Trottier-Duclos F, Desbeaumes Jodoin V, Fournier-Gosselin MP, Richer F, Desjardins N, Tieu S, Lespérance P.

Journal of ECT • Volume 00, Number 00, Month 2018

Rodrigo Silva 4/12/22 Rodrigo Silva 4/12/22

Quality-of-life metrics with vagus nerve stimulation for epilepsy from provider survey data

Englot DJ, Hassnain KH, Rolston JD, Harward SC, Sinha SR, Haglund MM.

Epilepsy & Behavior 66 (2017) 4–9

Rodrigo Silva 4/7/22 Rodrigo Silva 4/7/22

Effects of Stable Vagus Nerve Stimulation Efficacy on Autistic Behaviors in Ten Pediatric Patients With Drug Resistant Epilepsy: An Observational Study

Front Pediatr. 2022 Mar 2;10:846301.

Rodrigo Silva 4/1/22 Rodrigo Silva 4/1/22

The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: The PuLsE (Open Prospective Randomized Long-term Effectiveness) trial

Ryvlin P, Gilliam FG, Nguyen DK, Colicchio G, Iudice A, Tinuper P, Zamponi N, Aguglia U, Wagner L, Minotti L, Stefan H, Boon P, Sadler M, Benna P, Raman P, Perucca E.

Epilepsia, 55(6):893–900, 2014

Rodrigo Silva 3/31/22 Rodrigo Silva 3/31/22

Efficacy and tolerability of vagus nerve stimulation therapy (VNS) in Slovenian epilepsy patients: younger age and shorter duration of epilepsy might result in better outcome

Kavčič A, Kajdič N, Rener-Primec Z, Krajnc N, Žgur T.

Acta Clin Croat. 2019 Jun; 58(2): 255–264.

Rodrigo Silva 3/30/22 Rodrigo Silva 3/30/22

Setting Up a Successful Vagus Nerve Stimulation Service for Patients With Difficult-to-Treat Depression

Kraus C, Quach D, Sholtes DM, Kavakbasi E, De Zwaef R, Dibué M, Zajecka J, Baune BT.

Neuromodulation. 2022 Feb 2;S1094-7159(21)06988-9.

Rodrigo Silva 3/25/22 Rodrigo Silva 3/25/22

Vagus nerve stimulation: An update on a novel treatment for treatment-resistant depression

Kamel LY, Xiong W, Gott BM, Kumar A, Conway CR.

J Neurol Sci. 2022 Mar 15;434:120171.

Rodrigo Silva 3/25/22 Rodrigo Silva 3/25/22

Successful outcome of episodes of status epilepticus after vagus nerve stimulation: a multicenter study

Sierra-Marcos A, Maestro I, Rodríguez-Osorio X, Miró J, Donaire A, Aparicio J, Rumiá J, Forcadas M, Garamendi I, Pardo J, López J, Prieto Á, Plans G, Falip M, Carreño M.

Eur J Neurol. 2012 Sep;19(9):1219-23.

$Vagus nerve stimulation in refractory and super-refractory status epilepticus - A systematic review$