Scientific Summaries
At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.
Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.
Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.
The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy: a meta-analysis.
Many caregivers are concerned about the potential long-term effects of using antiseizure medications (#ASMs) and how it may affect their children’s intelligence.
Long-term outcomes and prognosis factors of vagus nerve stimulation in patients with refractory epilepsy
Cuiping X, Hua L, Jiwen X, Xiaohua Z, Guiliang H, Qiang Qiang L, Chengyun D, Shan W, Quanjun Z, Xiaojun B, Kui C, Duanyu N, Yongjie L, Tao Y, Yuping W.
Acta Epileptologica 4, 38 (2022).
Efficacy and potential predictors of vagus nerve stimulation therapy in refractory postencephalitic epilepsy
Liu S, Xiong Z, Wang J, Tang C, Deng J, Zhang J, Guo M, Guan Y, Zhou J, Zhai F, Luan G, Li T.
Ther Adv Chronic Dis 2022, Vol. 13: 1–13
A prediction model integrating synchronization biomarkers and clinical features to identify responders to vagus nerve stimulation among pediatric patients with drug-resistant epilepsy
Ma J, Wang Z, Cheng T, Hu Y, Qin X, Wang W, Yu G, Liu Q, Ji T, Xie H, Zha D, Wang S, Yang Z, Liu X, Cai L, Jiang Y, Hao H, Wang J, Li L, Wu Y.
CNS Neurosci Ther. 2022 Jul 27
Quantifying the burden of disease in patients with Lennox Gastaut syndrome
Spoor JKH, Greco T, Kamp MA, Faini S, Senft C, Dibué M.
Behav Rep. 2021 Nov 25;16:100508.
Vagus nerve stimulation for super-refractory status epilepticus in febrile infection–related epilepsy syndrome: a pediatric case report and literature review
Luo T, Wang Y, Lu G, Zhou Y, Wang Y.
Childs Nerv Syst. 2022 Jul;38(7):1401-1404.
Predictors of vagus nerve stimulation complications among pediatric patients with drug-resistant epilepsy
Muthiah N, Sharma N, Vodovotz L, White GE, Abel TJ.
J Neurosurg Pediatr. 2022 Jul 8:1-8.
Comparison of traditional and closed loop vagus nerve stimulation for treatment of pediatric drug-resistant epilepsy: A propensity-matched retrospective cohort study
Muthiah N, Akwayena E, Vodovotz L, Sharma N, Jeong JH, White GE, Abel TJ.
Seizure. 2022 Jan;94:74-81.
VNS parameters for clinical response in epilepsy
Fahoum F, Boffini M, Kann L, Faini S, Gordon C, Tzadok M, El Tahry R.
Brain Stimul. 2022 May-Jun;15(3):814-821.
Short- and Long-Term Response of Vagus Nerve Stimulation Therapy in Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis
Mao H, Chen Y, Ge Q, Ye L, Cheng H.
Neuromodulation. 2022 Apr;25(3):327-342.
Closed-Loop Vagus Nerve Stimulation for the Treatment of Cardiovascular Diseases: State of the Art and Future Directions
Ottaviani MM, Vallone F, Micera S, Recchia FA.
Front Cardiovasc Med. 2022 Apr 7;9:866957.
Preoperative Heart Rate Variability During Sleep Predicts Vagus Nerve Stimulation Outcome Better in Patients With Drug-Resistant Epilepsy
Fang X, Liu HY, Wang ZY, Yang Z, Cheng TY, Hu CH, Hao HW, Meng FG, Guan YG, Ma YS, Liang SL, Lin JL, Zhao MM, Li LM.
Front Neurol. 2021 Jul 7;12:691328.
Vagus nerve stimulation for difficult to treat depression
Reif-Leonhard C, Reif A, Baune BT, Kavakbasi E.
Nervenarzt. 2022 Apr 5.
Difficult-to-Treat Depression and the Role of Vagus Nerve Stimulation
R. Hamish McAllister-Williams, PhD, MD, FRCPsych and Tiago Costa, MBBS, MRCPsych
Psychiatr Ann. 2022;52(7):266–271 English.
Clinician preferences for neurotechnologies in pediatric drug- resistant epilepsy: A discrete choice experiment
Glory O. Apantaku, Patrick J. McDonald, Magda Aguiar, Laura Y. Cabrera, Winston Chiong, Mary B. Connolly, Viorica Hrincu, George M. Ibrahim, K. Julia Kaal, Ashley Lawson, Robert Naftel, Eric Racine, Abdollah Safari, Mark Harrison, Judy Illes
Epilepsia. 2022;00:1–12
Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
Pitkänen A, Sutula TP.
Lancet Neurol. 2002 Jul;1(3):173-81.
Up to What Extent Does Dravet Syndrome Benefit From Neurostimulation Techniques?
Jiangwei Ding, Lei Wang, Wenchao Li, Yangyang Wang, Shucai Jiang, Lifei Xiao, Changliang Zhu, Xiaoyan Hao, Jiali Zhao, Xuerui Kong, Ziqin Wang, Guangyuan Lu, Feng Wang and Tao Sun
Front Neurol. 2022 Apr 13;13:843975
Clinical perspectives on vagus nerve stimulation: present and future
This work by Goggins et al. (May 2022) reviewed the #preclinical and #clinical evidence for evaluating the treatment effect of vagus nerve stimulation (#VNS) in drug resistant epilepsy (#DRE).
Vagus nerve stimulation has a positive effect on mood in patients with refractory epilepsy
Klinkenberg S, Majoie HJ, van der Heijden MM, Rijkers K, Leenen L, Aldenkamp AP.
Clinical Neurology and Neurosurgery 114 (2012) 336–340
Vagal nerve stimulation for drug-resistant epilepsies in different age, aetiology and duration
Colicchio G, Policicchio D, Barbati G, Cesaroni E, Fuggetta F, Meglio M, Papacci F, Rychlicki F, Scerrati M, Zamponi N.
Child's Nervous System volume 26, pages811–819 (2010)