Scientific Summaries
At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.
Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.
Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.
Observations on the Use of Vagus Nerve Stimulation Earlier in the Course of Pharmacoresistant Epilepsy: Patients With Seizures for Six Years or Less
Helmers SL, Griesemer DA, Dean JC, Sanchez JD, Labar D, Murphy JV, Bettis D, Park YD, Shuman RM, Morris GL 3rd.
The Neurologist: May 2003 - Volume 9 - Issue 3 - p 160-164
Vagus Nerve Stimulation in Intractable Epilepsy
This study by Boluk et al. 2022 evaluated the efficiency and safety of vagus nerve stimulation (#VNS) in different types of #refractory epilepsy based on a single center experience at Istanbul University-Cerrahpasa, Turkey.
A surface electrode adjacent to vagal nerve stimulator lead can aid in characterizing vagal nerve stimulator mediated pediatric sleep-disordered breathing: a case series of 7 patients
A potential side effect associated with vagus nerve stimulation (#VNS) Therapy for drug resistant epilepsy (#DRE) is sleep-disordered breathing (#SDB).
Connectomic profiling and Vagus nerve stimulation Outcomes Study (CONNECTiVOS): a prospective observational protocol to identify biomarkers of seizure response in children and youth
Siegel L, Yan H, Warsi N, Wong S, Suresh H, Weil AG, Ragheb J, Wang S, Rozzelle C, Albert GW, Raskin J, Abel T, Hauptman J, Schrader DV, Bollo R, Smyth MD, Lew SM, Lopresti M, Kizek DJ, Weiner HL, Fallah A, Widjaja E, Ibrahim GM.
BMJ Open 2022;12:e055886.
Management and outcome of vagus nerve stimulator implantation: experience of an otolaryngeal/neuropediatric cooperation
Grasl S, Janik S, Dressler A, Diehm R, Gröppel G, Eichinger K, Grasl MC, Gstoettner W, Feucht M, Vyskocil E, Baumgartner WD.
European Archives of Oto-Rhino-Laryngology (2021) 278:3891–3899
Effects of Stable Vagus Nerve Stimulation Efficacy on Autistic Behaviors in Ten Pediatric Patients With Drug Resistant Epilepsy: An Observational Study
Effects of Stable Vagus Nerve Stimulation Efficacy on Autistic Behaviors in Ten Pediatric Patients With Drug Resistant Epilepsy: An Observational Study
Front Pediatr. 2022 Mar 2;10:846301.
Efficacy and tolerability of vagus nerve stimulation therapy (VNS) in Slovenian epilepsy patients: younger age and shorter duration of epilepsy might result in better outcome
Kavčič A, Kajdič N, Rener-Primec Z, Krajnc N, Žgur T.
Acta Clin Croat. 2019 Jun; 58(2): 255–264.
Setting Up a Successful Vagus Nerve Stimulation Service for Patients With Difficult-to-Treat Depression
Kraus C, Quach D, Sholtes DM, Kavakbasi E, De Zwaef R, Dibué M, Zajecka J, Baune BT.
Neuromodulation. 2022 Feb 2;S1094-7159(21)06988-9.
Super refractory status epilepticus in Lafora disease interrupted by vagus nerve stimulation: A case report
Mostacci B, Bisulli F, Muccioli L, Minardi I, Bandini M, Licchetta L, Zucchelli M, Leta C, Michelucci R, Zanello M, Tinuper P.
Brain Stimul. Nov-Dec 2019;12(6):1605-1607.
Vagus nerve stimulation: An update on a novel treatment for treatment-resistant depression
Kamel LY, Xiong W, Gott BM, Kumar A, Conway CR.
J Neurol Sci. 2022 Mar 15;434:120171.
Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option?
Specchio N, Ferretti A, Pietrafusa N, Trivisano M, Calabrese C, Carfì Pavia G, De Benedictis A, Marras CE, de Palma L, Vigevano F.
Front Neurol. 2020 Jun 12;11:443.
Vagus nerve stimulation in refractory and super-refractory status epilepticus - A systematic review
Dibué-Adjei M, Brigo F, Yamamoto T, Vonck K, Trinka E.
Brain Stimul. Sep-Oct 2019;12(5):1101-1110.
Vagus nerve stimulation for drug-resistant epilepsy induced by tuberous sclerosis complex
This study by Tong et al. (Jan. 2022) examined the long-term effects of vagus nerve stimulation (#VNS) for seizure control and its one-year impact on cognition and emotion of drug-resistant epilepsy (#DRE) patients induced by tuberous sclerosis complex (#TSC).
The effect of vagus nerve stimulator in controlling status epilepticus in children
Gedela S, Sitwat B, Welch WP, Krafty RT, Sogawa Y.
Seizure. VOLUME 55, P66-69, 2, 01, 2018
Vagus nerve stimulation therapy in people with drug-resistant epilepsy (CORE-VNS): rationale and design of a real-world post-market comprehensive outcomes registry.
Sen A, Verner R, Valeriano JP, Lee R, Zafar M, Thomas R, Kotulska K, Jespers E, Dibué M, Kwan P
BMJ Neurol Open 2021;3:e000218
The role of vagus nerve stimulation in the treatment of refractory epilepsy: clinical outcomes and impact onquality of life.
Martorell-Llobregat C, González-López P, Luna E, Asensio-Asensio M, Jadraque-Rodríguez R, García-March G, Moreno-López P.
Neurologia (Engl Ed). 2021 Jun1;S2173-5808(21)00073-0
Combined VNS-RNS Neuromodulation for Epilepsy
Khankhanian P, Lee AM, Drees CN, Decker BM, Becker DA.
Journal of Clinical Neurophysiology: February 2022,39,2,e5-e9
Brainstem Associated Somatosensory Evoked Potentials and Response to Vagus Nerve Stimulation: An Investigation of the Vagus Afferent Network
Suresh H, Mithani K, Brar K, Yan H, Strantzas S, Vandenberk M, Sharma R, Yau I, Go C, Pang E, Kerr E, Ochi A, Otsubo H, Jain P, Donner E, Snead OC, Ibrahim GM. #RetrospectiveStudy
Front. Neurol., 18 February 2022
Semiautomated classification of nocturnal seizures using video recordings
Peltola J, Basnyat P, Armand Larsen S, Østerkjaerhuus T, Vinding Merinder T, Terney D, Beniczky S.
Epilepsia. 2022;00:1–7.
Laryngeal Muscle-Evoked Potential Recording as an Indicator of Vagal Nerve Fiber Activation
Bouckaert C, Raedt R, Larsen LE, El Tahry R, Gadeyne S, Carrette E, Proesmans S, Dewaele F, Delbeke J, De Herdt V, Meurs A, Mertens A, Boon P, Vonck K.
Neuromodulation. 2022 Feb 14;S1094-7159(22)00035-6.