Scientific Summaries
At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.
Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.
Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.

Vagus nerve stimulation in refractory and super-refractory status epilepticus - A systematic review
Dibué-Adjei M, Brigo F, Yamamoto T, Vonck K, Trinka E.
Brain Stimul. Sep-Oct 2019;12(5):1101-1110.

Vagus nerve stimulation for drug-resistant epilepsy induced by tuberous sclerosis complex
This study by Tong et al. (Jan. 2022) examined the long-term effects of vagus nerve stimulation (#VNS) for seizure control and its one-year impact on cognition and emotion of drug-resistant epilepsy (#DRE) patients induced by tuberous sclerosis complex (#TSC).

The effect of vagus nerve stimulator in controlling status epilepticus in children
Gedela S, Sitwat B, Welch WP, Krafty RT, Sogawa Y.
Seizure. VOLUME 55, P66-69, 2, 01, 2018

Vagus nerve stimulation therapy in people with drug-resistant epilepsy (CORE-VNS): rationale and design of a real-world post-market comprehensive outcomes registry.
Sen A, Verner R, Valeriano JP, Lee R, Zafar M, Thomas R, Kotulska K, Jespers E, Dibué M, Kwan P
BMJ Neurol Open 2021;3:e000218

The role of vagus nerve stimulation in the treatment of refractory epilepsy: clinical outcomes and impact onquality of life.
Martorell-Llobregat C, González-López P, Luna E, Asensio-Asensio M, Jadraque-Rodríguez R, García-March G, Moreno-López P.
Neurologia (Engl Ed). 2021 Jun1;S2173-5808(21)00073-0

Combined VNS-RNS Neuromodulation for Epilepsy
Khankhanian P, Lee AM, Drees CN, Decker BM, Becker DA.
Journal of Clinical Neurophysiology: February 2022,39,2,e5-e9

Brainstem Associated Somatosensory Evoked Potentials and Response to Vagus Nerve Stimulation: An Investigation of the Vagus Afferent Network
Suresh H, Mithani K, Brar K, Yan H, Strantzas S, Vandenberk M, Sharma R, Yau I, Go C, Pang E, Kerr E, Ochi A, Otsubo H, Jain P, Donner E, Snead OC, Ibrahim GM. #RetrospectiveStudy
Front. Neurol., 18 February 2022

Concurrent brain-responsive and vagus nerve stimulation for treatment of drug-resistant focal epilepsy
Brown MG, Sillau S, McDermott D, Ernst LD, Spencer DC, Englot DJ, González HFJ, Datta P, Karakis I, Becker D, Rolston JD, Arain A, Rao VR, Doherty M, Urban A, Drees C.
Epilepsy & Behavior Volume 129, April 2022, 108653

Norwegian population-based study of long-term effects, safety, and predictors of response of vagus nerve stimulation treatment in drug-resistant epilepsy: The NORPulse study.
Many caregivers are concerned about the potential long-term effects of using antiseizure medications (#ASMs) and how it may affect their children’s intelligence.

Semiautomated classification of nocturnal seizures using video recordings
Peltola J, Basnyat P, Armand Larsen S, Østerkjaerhuus T, Vinding Merinder T, Terney D, Beniczky S.
Epilepsia. 2022;00:1–7.

Laryngeal Muscle-Evoked Potential Recording as an Indicator of Vagal Nerve Fiber Activation
Bouckaert C, Raedt R, Larsen LE, El Tahry R, Gadeyne S, Carrette E, Proesmans S, Dewaele F, Delbeke J, De Herdt V, Meurs A, Mertens A, Boon P, Vonck K.
Neuromodulation. 2022 Feb 14;S1094-7159(22)00035-6.

Neuromodulation in Intractable Epilepsy Through Responsive Vagal Nerve Stimulation: A Three-Year Retrospective Study at the University of Texas Medical Branch, Galveston
Villarreal J, Valaparla VL, Curtis K, Thottempudi N, Elrahi S, Gil Guevara A, Gogia B, Sun R, Masel T, Rai P.
Cureus 13(10): e18698.

Automated detection of absence seizures using a wearable electroencephalographic device: a phase 3 validation study and feasibility of automated behavioral testing.
Japaridze G, Loeckx D, Buckinx T, Armand Larsen S, Proost R, Jansen K, MacMullin P, Paiva N, Kasradze S, Rotenberg A, Lagae L, Beniczky S.
Epilepsia. 2022;00:1–7.

Dual-Device Neuromodulation in Epilepsy
Freund B, Grewal SS, Middlebrooks EH, Moniz-Garcia D, Feyissa AM, Tatum WO.
World Neurosurg. 2022 Feb 18;S1878-8750(22)00205-4

ILAE clinical practice recommendations for the medical treatment of depression in adults with epilepsy.
Mula M, Brodie MJ, de Toffol B, Guekht A, Hecimovic H, Kanemoto K, Kanner AM, Teixeira AL, Wilson SJ.
Epilepsia. 2022 Feb;63(2):316-334.

Combined use of the ketogenic diet and vagus nerve stimulation in pediatric drug‐resistant epilepsy
Wang, M., Geng, G., Meng, Y. et al.
Acta Epileptologica 4, 34 (2022).

Prevalence and associated risk factors of undiagnosed depression among people with epilepsy in a multiethnic society
Tan JK, Khoo CS, Beh HC, Hod R, Baharudin A, Yahya WNNW, Tan HJ.
Epilepsy Research Volume 178, December 2021, 106772

Effect of Long-Term Treatment with Vagus Nerve Stimulation on Mood and Quality of Life in Korean Patients with Drug-Resistant Epilepsy.
Kim JS, Kim DY, Jo HJ, Hwang YH, Song JY, Yang KI, Hong SB.
J Clin Neurol 2021;17(3):385-392


Combined ketogenic diet and vagus nerve stimulation: rational polytherapy?
Kossoff EH, Pyzik PL, Rubenstein JE, Bergqvist AG, Buchhalter JR, Donner EJ, Nordli DR Jr, Wheless JW.
Epilepsia. 2007 Jan;48(1):77-81.