Scientific Summaries
At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.
Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.
Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.
Accurate identification of EEG recordings with interictal epileptiform discharges using a hybrid approach: Artificial intelligence supervised by human experts
Kural MA, Jing J, Fürbass F, Perko H, Qerama E, Johnsen B, Fuchs S, Westover MB, Beniczky S.
Epilepsia. 2022;00:1–10.
Vagal nerve stimulation for drug-resistant epilepsies in different age, aetiology and duration
Colicchio G, Policicchio D, Barbati G, Cesaroni E, Fuggetta F, Meglio M, Papacci F, Rychlicki F, Scerrati M, Zamponi N.
Child's Nervous System volume 26, pages811–819 (2010)
Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design
Have a look at the study design of the upcoming PRediction of vagal nerve stimulation EfficaCy In drug-reSistant Epilepsy (PRECISE) study, by Dolezalova et al. 2022, that was recently published in frontiers in Neurology.
Subgroup analysis of seizure and cognitive outcome after vagal nerve stimulator implantation in children
Knorr C, Greuter L, Constantini S, Fried I, Kremer U, Datta AN, Guzman R, Soleman J.
Child's Nervous System volume 37, pages243–252 (2021)
Improved quality of life and cognition after early vagal nerve stimulator implantation in children
Soleman J, Stein M, Knorr C, Datta AN, Constantini S, Fried I, Guzman R, Kramer U.
Epilepsy & Behavior 88 (2018) 139–145
Observations on the Use of Vagus Nerve Stimulation Earlier in the Course of Pharmacoresistant Epilepsy: Patients With Seizures for Six Years or Less
Helmers SL, Griesemer DA, Dean JC, Sanchez JD, Labar D, Murphy JV, Bettis D, Park YD, Shuman RM, Morris GL 3rd.
The Neurologist: May 2003 - Volume 9 - Issue 3 - p 160-164
Vagus Nerve Stimulation in Intractable Epilepsy
This study by Boluk et al. 2022 evaluated the efficiency and safety of vagus nerve stimulation (#VNS) in different types of #refractory epilepsy based on a single center experience at Istanbul University-Cerrahpasa, Turkey.
A surface electrode adjacent to vagal nerve stimulator lead can aid in characterizing vagal nerve stimulator mediated pediatric sleep-disordered breathing: a case series of 7 patients
A potential side effect associated with vagus nerve stimulation (#VNS) Therapy for drug resistant epilepsy (#DRE) is sleep-disordered breathing (#SDB).
Connectomic profiling and Vagus nerve stimulation Outcomes Study (CONNECTiVOS): a prospective observational protocol to identify biomarkers of seizure response in children and youth
Siegel L, Yan H, Warsi N, Wong S, Suresh H, Weil AG, Ragheb J, Wang S, Rozzelle C, Albert GW, Raskin J, Abel T, Hauptman J, Schrader DV, Bollo R, Smyth MD, Lew SM, Lopresti M, Kizek DJ, Weiner HL, Fallah A, Widjaja E, Ibrahim GM.
BMJ Open 2022;12:e055886.
A 6-Year Follow-up Study of Vagus Nerve Stimulation Effect on Quality of Life in Treatment-Resistant Depression A Pilot Study
Trottier-Duclos F, Desbeaumes Jodoin V, Fournier-Gosselin MP, Richer F, Desjardins N, Tieu S, Lespérance P.
Journal of ECT • Volume 00, Number 00, Month 2018
Quality-of-life metrics with vagus nerve stimulation for epilepsy from provider survey data
Englot DJ, Hassnain KH, Rolston JD, Harward SC, Sinha SR, Haglund MM.
Epilepsy & Behavior 66 (2017) 4–9
Management and outcome of vagus nerve stimulator implantation: experience of an otolaryngeal/neuropediatric cooperation
Grasl S, Janik S, Dressler A, Diehm R, Gröppel G, Eichinger K, Grasl MC, Gstoettner W, Feucht M, Vyskocil E, Baumgartner WD.
European Archives of Oto-Rhino-Laryngology (2021) 278:3891–3899
Effects of Stable Vagus Nerve Stimulation Efficacy on Autistic Behaviors in Ten Pediatric Patients With Drug Resistant Epilepsy: An Observational Study
Effects of Stable Vagus Nerve Stimulation Efficacy on Autistic Behaviors in Ten Pediatric Patients With Drug Resistant Epilepsy: An Observational Study
Front Pediatr. 2022 Mar 2;10:846301.
The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: The PuLsE (Open Prospective Randomized Long-term Effectiveness) trial
Ryvlin P, Gilliam FG, Nguyen DK, Colicchio G, Iudice A, Tinuper P, Zamponi N, Aguglia U, Wagner L, Minotti L, Stefan H, Boon P, Sadler M, Benna P, Raman P, Perucca E.
Epilepsia, 55(6):893–900, 2014
Efficacy and tolerability of vagus nerve stimulation therapy (VNS) in Slovenian epilepsy patients: younger age and shorter duration of epilepsy might result in better outcome
Kavčič A, Kajdič N, Rener-Primec Z, Krajnc N, Žgur T.
Acta Clin Croat. 2019 Jun; 58(2): 255–264.
Setting Up a Successful Vagus Nerve Stimulation Service for Patients With Difficult-to-Treat Depression
Kraus C, Quach D, Sholtes DM, Kavakbasi E, De Zwaef R, Dibué M, Zajecka J, Baune BT.
Neuromodulation. 2022 Feb 2;S1094-7159(21)06988-9.
Super refractory status epilepticus in Lafora disease interrupted by vagus nerve stimulation: A case report
Mostacci B, Bisulli F, Muccioli L, Minardi I, Bandini M, Licchetta L, Zucchelli M, Leta C, Michelucci R, Zanello M, Tinuper P.
Brain Stimul. Nov-Dec 2019;12(6):1605-1607.
Vagus nerve stimulation: An update on a novel treatment for treatment-resistant depression
Kamel LY, Xiong W, Gott BM, Kumar A, Conway CR.
J Neurol Sci. 2022 Mar 15;434:120171.
Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option?
Specchio N, Ferretti A, Pietrafusa N, Trivisano M, Calabrese C, Carfì Pavia G, De Benedictis A, Marras CE, de Palma L, Vigevano F.
Front Neurol. 2020 Jun 12;11:443.
Successful outcome of episodes of status epilepticus after vagus nerve stimulation: a multicenter study
Sierra-Marcos A, Maestro I, Rodríguez-Osorio X, Miró J, Donaire A, Aparicio J, Rumiá J, Forcadas M, Garamendi I, Pardo J, López J, Prieto Á, Plans G, Falip M, Carreño M.
Eur J Neurol. 2012 Sep;19(9):1219-23.