Scientific Summaries
At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.
Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.
Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.
Vagus nerve stimulation in children with drug-resistant epilepsy of monogenic etiology
Xie H, Ma J, Ji T, Liu Q, Cai L, Wu Y.
Front Neurol. 2022 Sep 1;13:951850.
Efficacy and potential predictors of vagus nerve stimulation therapy in refractory postencephalitic epilepsy
Liu S, Xiong Z, Wang J, Tang C, Deng J, Zhang J, Guo M, Guan Y, Zhou J, Zhai F, Luan G, Li T.
Ther Adv Chronic Dis 2022, Vol. 13: 1–13
Evaluating vagus nerve stimulation treatment with heart rate monitoring in pediatric patients with intractable epilepsy
Brandon Santhumayor, Shefali Karkare, Sanjeev Kothare & Shaun Rodgers
Epileptic Disord. 2022 Oct 1;24(5):1-12.
Long-term results of vagus nerve stimulation in children with Dravet syndrome: Time-dependent, delayed antiepileptic effect
Youn SE, Jung DE, Kang HC, Kim HD.
Epilepsy Res. 2021 Aug;174:106665.
Neuromodulation in drug-resistant epilepsy: A review of current knowledge
Xue T, Chen S, Bai Y, Han C, Yang A, Zhang J.
Acta Neurol Scand. 2022 Sep 5.
Patient-Specific Characteristics Associated with Favorable Response to Vagus Nerve Stimulation
Riestenberg RA, Sherman AE, Clark AJS, Shahlaie K, Zwienenberg M, Alden T, Bandt SK
World Neurosurg. 2022 May;161:e608-e624.
Vagus Nerve Stimulation in Children with Refractory Seizures Associated with Lennox–Gastaut Syndrome
Frost M, Gates J, Helmers SL, Wheless JW, Levisohn P, Tardo C, Conry JA.
Epilepsia. 2001 Sep;42(9):1148-52.
Vagus nerve stimulation in patients with therapy-resistant generalized epilepsy
Suller Marti A, Mirsattari SM, MacDougall K, Steven DA, Parrent A, de Ribaupierre S, Andrade A, Diosy D, McLachlan RS, Burneo JG.
Epilepsy Behav. 2020 Oct;111:107253.
Practical considerations in epilepsy neurostimulation
Simpson HD, Schulze-Bonhage A, Cascino GD, Fisher RS, Jobst BC, Sperling MR, Lundstrom BN
Epilepsia. 2022 Oct;63(10):2445-2460.
Nonpharmacologic care for patients with Lennox-Gastautsyndrome: Ketogenic diets and vagus nerve stimulation
Kossoff EH, Shields WD.
Epilepsia. 2014 Sep;55 Suppl 4:29-33.
The efficacy and tolerability of auto-stimulation-VNS in children with Lennox-Gastaut syndrome
Kossoff EH, Shields WD.
Epilepsia. 2014 Sep;55 Suppl 4:29-33.
Cumulative effects of antiseizure medication on intelligence in children with focal epilepsy
Stevering CH, Lamberink HJ, Woodfield J, van Schooneveld M, Otte WM, Chin RFM, Bastin ME, Geleijns K, Braun KPJ.
Epileptic Disord. 2022 Oct 1;24(5):1-12. English.
Rapid titration of VNS therapy reduces time-to-response in epilepsy
Tzadok M, Verner R, Kann L, Tungala D, Gordon C, El Tahry R, Fahoum F.
Epilepsy Behav. 2022 Sep;134:108861.
Immediate Effects of Vagal Nerve Stimulation in Drug-Resistant Epilepsy Revealed by Magnetoencephalographic Recordings
Li Y, Zhu H, Chen Q, Yang L, Chen F, Ma H, Xu H, Chen K, Bu J, Zhang R.
Brain Connect. 2022 Sep 15.
Yield and risk associated with prolonged presurgical video-EEG monitoring: a systematic review
van Griethuysen R, van Asch CJJ, Otte WM, Sander JW, Braun KPJ.
Epileptic Disord. 2022 Dec 1;24(6):1-13. English.
Vagus nerve stimulation outcome prediction: from simple parameters to advanced models
Chrastina J, Novak Z, Zeman T, Dolezalova I, Zatloukalova E, Brazdil M.
Bratisl Lek Listy. 2022;123(9):641-647.
Vagus nerve stimulation in patients with Lennox-Gastaut syndrome: A meta-analysis
Dibué M, Greco T, Spoor JKH, Tahir Z, Specchio N, Hänggi D, Steiger HJ, Kamp MA.
Acta Neurol Scand. 2021 May;143(5):497-508.
Long-term outcome of convulsive status epilepticus: a 10-year follow-up
Kling R, Ritvanen J, Mustonen H, Kämppi L.
Epileptic Disord. 2022 Dec 1;24(6):1-14. English.
Vagus nerve stimulation and Lennox-Gastaut syndrome: a review of the literature and data from the VNS patient registry
Karceski S.
CNS Spectr. 2001 Sep;6(9):766-70.
A prediction model integrating synchronization biomarkers and clinical features to identify responders to vagus nerve stimulation among pediatric patients with drug-resistant epilepsy
Ma J, Wang Z, Cheng T, Hu Y, Qin X, Wang W, Yu G, Liu Q, Ji T, Xie H, Zha D, Wang S, Yang Z, Liu X, Cai L, Jiang Y, Hao H, Wang J, Li L, Wu Y.
CNS Neurosci Ther. 2022 Jul 27