Scientific Summaries

At Go North Medical, evidence is the cornerstone of our mission to target the right patients at the right time. In the area of Neurology alone, over 100 articles, case studies, and other resources are published each week. To deepen the company's understanding of the field, the medical team, led by Medical Affairs Manager Martina Boström, extracts key insights from these publications. All medical team members have a research background and possess expertise in critically reviewing evidence to determine both its strengths and weaknesses.

Primarily, the team stays up-to-date with the latest scientific evidence on vagus nerve stimulation therapy and evaluates its effectiveness through critical review and analysis of relevant publications. Part of this effort is published here, with scientific summaries and reflections created by the team. These summaries emphasize the most important publications that are relevant to our field of expertise.

Please don’t hesitate to contact us if you are unable to find clinical evidence related to a particular area of interest.

Rodrigo Silva 10/12/22 Rodrigo Silva 10/12/22

Practical considerations in epilepsy neurostimulation

Simpson HD, Schulze-Bonhage A, Cascino GD, Fisher RS, Jobst BC, Sperling MR, Lundstrom BN

Epilepsia. 2022 Oct;63(10):2445-2460.

Rodrigo Silva 10/6/22 Rodrigo Silva 10/6/22

Nonpharmacologic care for patients with Lennox-Gastautsyndrome: Ketogenic diets and vagus nerve stimulation

Kossoff EH, Shields WD.

Epilepsia. 2014 Sep;55 Suppl 4:29-33.

Rodrigo Silva 10/6/22 Rodrigo Silva 10/6/22

The efficacy and tolerability of auto-stimulation-VNS in children with Lennox-Gastaut syndrome

Kossoff EH, Shields WD.

Epilepsia. 2014 Sep;55 Suppl 4:29-33.

Rodrigo Silva 9/30/22 Rodrigo Silva 9/30/22

Rapid titration of VNS therapy reduces time-to-response in epilepsy

Tzadok M, Verner R, Kann L, Tungala D, Gordon C, El Tahry R, Fahoum F.

Epilepsy Behav. 2022 Sep;134:108861.

Rodrigo Silva 9/30/22 Rodrigo Silva 9/30/22

Immediate Effects of Vagal Nerve Stimulation in Drug-Resistant Epilepsy Revealed by Magnetoencephalographic Recordings

Li Y, Zhu H, Chen Q, Yang L, Chen F, Ma H, Xu H, Chen K, Bu J, Zhang R.

Brain Connect. 2022 Sep 15.

Rodrigo Silva 9/22/22 Rodrigo Silva 9/22/22

Yield and risk associated with prolonged presurgical video-EEG monitoring: a systematic review

van Griethuysen R, van Asch CJJ, Otte WM, Sander JW, Braun KPJ.

Epileptic Disord. 2022 Dec 1;24(6):1-13. English.

Rodrigo Silva 9/16/22 Rodrigo Silva 9/16/22

Vagus nerve stimulation outcome prediction: from simple parameters to advanced models

Chrastina J, Novak Z, Zeman T, Dolezalova I, Zatloukalova E, Brazdil M.

Bratisl Lek Listy. 2022;123(9):641-647.

Rodrigo Silva 9/13/22 Rodrigo Silva 9/13/22

Vagus nerve stimulation in patients with Lennox-Gastaut syndrome: A meta-analysis

Dibué M, Greco T, Spoor JKH, Tahir Z, Specchio N, Hänggi D, Steiger HJ, Kamp MA.

Acta Neurol Scand. 2021 May;143(5):497-508.

Rodrigo Silva 9/7/22 Rodrigo Silva 9/7/22

Long-term outcome of convulsive status epilepticus: a 10-year follow-up

Kling R, Ritvanen J, Mustonen H, Kämppi L.

Epileptic Disord. 2022 Dec 1;24(6):1-14. English.

Rodrigo Silva 9/6/22 Rodrigo Silva 9/6/22

Vagus nerve stimulation and Lennox-Gastaut syndrome: a review of the literature and data from the VNS patient registry

Karceski S.

CNS Spectr. 2001 Sep;6(9):766-70.

Rodrigo Silva 8/31/22 Rodrigo Silva 8/31/22

Quantifying the burden of disease in patients with Lennox Gastaut syndrome

Spoor JKH, Greco T, Kamp MA, Faini S, Senft C, Dibué M.

Behav Rep. 2021 Nov 25;16:100508.

Rodrigo Silva 8/18/22 Rodrigo Silva 8/18/22

Automated detection of nocturnal motor seizures using an audio-video system

Armand Larsen S, Terney D, Østerkjerhuus T, Vinding Merinder T, Annala K, Knight A, Beniczky S.

Brain Behav. 2022 Aug 8:e2737

$Vagus nerve stimulation for refractory posttraumatic epilepsy: Efficacy and predictors of seizure outcome$

Rodrigo Silva 7/31/22 Rodrigo Silva 7/31/22

Vagus nerve stimulation for refractory posttraumatic epilepsy: Efficacy and predictors of seizure outcome

Guo M, Wang J, Tang C, Deng J, Zhang J, Xiong Z, Liu S, Guan Y, Zhou J, Zhai F, Luan G, Li T

Front Neurol. 2022 Jul 28;13:954509

Rodrigo Silva 7/27/22 Rodrigo Silva 7/27/22

VNS parameters for clinical response in epilepsy

Fahoum F, Boffini M, Kann L, Faini S, Gordon C, Tzadok M, El Tahry R.

Brain Stimul. 2022 May-Jun;15(3):814-821.

Rodrigo Silva 7/14/22 Rodrigo Silva 7/14/22

Closed-Loop Vagus Nerve Stimulation for the Treatment of Cardiovascular Diseases: State of the Art and Future Directions

Ottaviani MM, Vallone F, Micera S, Recchia FA.

Front Cardiovasc Med. 2022 Apr 7;9:866957.

Rodrigo Silva 7/13/22 Rodrigo Silva 7/13/22

Preoperative Heart Rate Variability During Sleep Predicts Vagus Nerve Stimulation Outcome Better in Patients With Drug-Resistant Epilepsy

Fang X, Liu HY, Wang ZY, Yang Z, Cheng TY, Hu CH, Hao HW, Meng FG, Guan YG, Ma YS, Liang SL, Lin JL, Zhao MM, Li LM.

Front Neurol. 2021 Jul 7;12:691328.

Rodrigo Silva 7/6/22 Rodrigo Silva 7/6/22

Vagus nerve stimulation for difficult to treat depression

Reif-Leonhard C, Reif A, Baune BT, Kavakbasi E.

Nervenarzt. 2022 Apr 5.

Rodrigo Silva 7/1/22 Rodrigo Silva 7/1/22

Difficult-to-Treat Depression and the Role of Vagus Nerve Stimulation

R. Hamish McAllister-Williams, PhD, MD, FRCPsych and Tiago Costa, MBBS, MRCPsych

Psychiatr Ann. 2022;52(7):266–271 English.

Rodrigo Silva 6/17/22 Rodrigo Silva 6/17/22

Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs

Iman Habibagahi, Mahmoud Omidbeigi, Joseph Hadaya, Hongming Lyu, Jaeeun Jang, Jeffrey L. Ardell, Ausaf A. Bari & Aydin Babakhani

Scientifc Reports | (2022) 12:8184

Rodrigo Silva 6/16/22 Rodrigo Silva 6/16/22

Feasibility of video/audio monitoring in the analysis of motion and treatment effects on night-time seizures – Interventional study

Ojanen P, Zabihi M, Knight A, Roivainen R, Lamusuo S, Peltola J.

Epilepsy Research 184 (2022) 106949